Modelling Nanomaterial Toxicity

Information about the MODENA Cost Action Programme

What is COST Action TD1204? 


Nanotechnology produces engineered nanomaterials (ENM) having new or enhanced physico-chemical properties in comparison to their micron-sized counterparts. Some of these properties, like the high surface area to volume ratio, make them potentially dangerous to humans as shown by research in NANOTOXICOLOGY. 


To promote the development of a new generation of ENM that are SAFE-by-DESIGN, an understanding of the relationship between the ENM STRUCTURE and the biological ACTIVITY is needed. In this context, Quantitative Nanostructure-Toxicity Relationships (QNTR) computational modelling technique is an effective alternative to experimental testing since it enables the prediction of (eco)-toxicological effects based on ENM structure only. 


The construction of QNTR model requires the integration of expertise of nanomaterial scientists, (eco)-toxicologists, and modellers from academia, regulatory agencies and industry. Therefore, a network for trans-disciplinary cooperation is needed. Thus, we propose the MODENACOST Action to promote and to realise through the coordination of these inter-disciplinary collaborations of different parties with the ultimate aim of producing QNTR models for ENM. 


The important benefits from MODENA include:


(i) the development of a new generation of SAFE-by-DESIGN ENM; 

(ii) the effective reduction of animal testing and 

(iii) The creation of transparent, validated and rigorous QNTR tools for regulatory purposes in the field of nanotoxicology according to OECD principles. 


 What is the COST MNPS Domain?   


The Domain Materials, Physics and Nanosciences (MPNS) is home to material science, extending from conception through to production and includes characterization, examination, evaluation, fabrication and development, to actual application and service, as well as related databases, codes, standards and inspections. The Domain thus also incorporates nanomaterials and nanosciences and the nanotechnological applications thereof. It also supports exploratory basic and applied research in physics, theoretical and experimental, as a key to understanding the laws governing the behaviour of matter and energy. COST is an intergovernmental framework for European Cooperation in Science and Technology, allowing the coordination of nationally-funded research on a European level. 


Further information on the European Cooperation in Science and Technology Initiative is available here, and more specifically on MODENA within the initiative here.


  • Chair of the Action:
    Prof Lang TRAN (UK)
  • Vice Chair of the Action:
    Prof Miguel BANARES (ES)
  • DC Rapporteurs:
    Prof. Pavle ANDJUS (RS)
  • DC Rapporteurs:
    Prof Lukas ROHR (CH) 
  • DC Rapporteurs:
    Prof. Venceslav KAUCIC (SI) 
  • Science officer of the Action:
    Dr Caroline WHELAN 
  • Administrative officer of the Action:
    Milena STOYANOVA
  • Grant Holder of the Action: 
    Bryony ROSS (UK)
  • Grant Holder of the Action: 
    Susan MAKARI (UK)